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KMID : 0352720060300040199
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Journal of Ginseng Research
2006 Volume.30 No. 4 p.199 ~ p.205
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Effects of Korean Ginseng(Panax Ginseng, C. A. Meyer) Extracts on Rat Exposed to Heat Environment
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Hong Hee-Do
Kim Young-Chan
Choi Sang-Yoon
Rho Jeong-Hae
Lee Young-Chul
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Abstract
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It was investigated that how the periodic exposure to heat environment, and the treatment of korean white and red ginseng extracts had effects on the weight, diet uptake, blood components, organ weight, and the lipid peroxidation of liver in male S.D. rats. In the result of experiments using rats, chronic heat environment for 7 days at $38^{\circ}C$, 5 hrs per day, induced significant decrease of an average increase rate of body weight, but diet uptake was not affected clearly. In heat environment, the number of red blood cells and hemoglobin were not changed, but the number of white blood cells was significantly increased. The liver weight against body weight was decreased in rats. Also, MDA contents, related to lipid peroxidation, were remarkably increased in rat liver by heat environment. These physiological changes were attenuated by treatments of white and red ginseng extracts before and after exposure to heat environment, particularly in growth rate and lipid peroxidation of liver in rats. Also, red ginseng extracts had a better effect, though it was not that significant, than the white ginseng on the inhibition of lipid peroxidation and the weight change of liver. Although the investigation on the effective components and the study on the activity changes of associated materials are needed to perform, these present results imply that Korean ginseng may contribute to protection of body homeostasis against drastic climate changes.
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KEYWORD
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korean ginseng extract, rat, heat environment, physiological properties
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